Employment and transport arguments can change block by block in Santiago. Look at the actual route tenants would take, nearby competing rentals and who the current occupants are. City-level strength cannot rescue a property whose immediate location or configuration limits demand.
Getting the comparison wrong could make a coastal asking-price range look like evidence for Marrakech when it is only background noise. I would ask for completed sales from each target neighbourhood and, crucially, the reason comparable listings were withdrawn: sold elsewhere, relisted, or...